Once known etiologies are excluded, then considered idiopathic • By mid-2000s, idiopathic neonatal hepatitis (INH) comprised only 15-30% of neonatal cholestasis due to increased ability to detect and diagnose metabolic and…
Often classified as having high-grade dysplasia given architectural complexity • Neoplastic cells have abundant granular eosinophilic cytoplasm with large nuclei, prominent nucleoli • Both intracytoplasmic and intercellular lumina found, many containing mucin,…
Pale, enlarged hepatocytes may be mistaken for normal or interpreted as fixation artifact • Fatty liver disease Pale, enlarged hepatocytes may be misinterpreted as ballooning hepatocyte degeneration • Glycogen storage disease No…
Characterized by ground-glass or smudged nuclei with margination of chromatin • Multinucleated cells with nuclear molding are less common compared with mucocutaneous HSV infections • Immunohistochemistry with antibodies directed against HSV1/HSV2 confirm…
Infected hepatocytes may be slightly enlarged and multinucleated May show hemorrhagic appearance in areas of necrosis • Varicella-zoster virus hepatitis • CMV hepatitis Gross AppearanceThis liver specimen from an autopsy case shows…
Pseudocyst on CTCT shows a unilocular cyst located in the head of the pancreas, consistent with a pancreatic pseudocyst . Pseudocyst With Hemorrhagic FluidGross photograph shows a pseudocyst in the…
Distinguished clinically • Hereditary fructose intolerance Distinct ultrastructural features • Neonatal hemochromatosis Diagnostic Checklist • Fibrosis with variable amounts of steatosis and cholestasis; requires clinical correlation • High risk of hepatocellular carcinoma Micronodular Cirrhosis…
Marked CongestionIn severe cases, venoocclusive disease is characterized by marked congestion in the sinusoids and can be accompanied by areas of hemorrhage . Congestion and Plate AtrophyEndothelial injury in sinusoids…
Grossly Evident PigmentGross photograph of liver core biopsies embedded in the paraffin block show dark regions corresponding to the pigment within centrizonal hepatocytes. Cytoplasmic PigmentH&E section shows coarse granular pigment…
Cytoplasmic PigmentH&E at high power shows lipofuscin pigment in centrizonal hepatocytes. PAS-D StainPeriodic acid-Schiff with diastase digestion accentuates the granular pigment in centrizonal hepatocytes , even though the pigment is…
