Glandular component may contain conventional ductal-type, clear cell, or signet ring cell components
Top Differential Diagnoses
![image](/wp-content/uploads/2017/04/image02919.jpeg)
Primary adenosquamous cell carcinoma in the tail of the pancreas shows a relatively well-demarcated, tan-white to yellow solid mass
![image](/wp-content/uploads/2017/04/image02920.jpeg)
![image](/wp-content/uploads/2017/04/image02921.jpeg)
![image](/wp-content/uploads/2017/04/image02922-1.jpeg)
Adenosquamous cell carcinoma of the pancreas demonstrates islands of malignant squamous cells with keratinization
![image](/wp-content/uploads/2017/04/image02923.jpeg)
![image](/wp-content/uploads/2017/04/image02924-1.jpeg)
![image](/wp-content/uploads/2017/04/image02925-1.jpeg)
Immunohistochemical stain for p63 shows nuclear staining in the squamous component
![image](/wp-content/uploads/2017/04/image02926-1.jpeg)
![image](/wp-content/uploads/2017/04/image02924-2.jpeg)
ETIOLOGY/PATHOGENESIS
Neoplastic
• A few hypotheses attempt to explain origin of squamous component
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![](https://freepngimg.com/download/social_media/63059-media-icons-telegram-twitter-blog-computer-social.png)
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