Glandular component may contain conventional ductal-type, clear cell, or signet ring cell components
Top Differential Diagnoses
Primary adenosquamous cell carcinoma in the tail of the pancreas shows a relatively well-demarcated, tan-white to yellow solid mass
with a cystic component 
.
Adenosquamous cell carcinoma of the pancreas demonstrates islands of malignant squamous cells with keratinization
adjacent to high-grade pancreatic intraepithelial neoplasia involving an interlobular duct 
.
Immunohistochemical stain for p63 shows nuclear staining in the squamous component
of adenosquamous cell carcinoma, while the glandular component is negative 
.
, while the squamous component 
is negative.
