Chronic myelogenous leukemia
CHAPTER 24 Chronic myelogenous leukemia G. Büsche, HH. Kreipe Chapter contents INTRODUCTION 361 CLINICAL FEATURES AND COURSE OF DISEASE 361 DIAGNOSTIC PROCEDURES 362 Genetics 362 Morphology 363 At diagnosis 363…
Abnormalities of the structure and synthesis of hemoglobin
CHAPTER 9 Abnormalities of the structure and synthesis of hemoglobin SL. Thein Chapter contents INTRODUCTION 131 NORMAL HUMAN HEMOGLOBIN: STRUCTURE AND SYNTHESIS 131 INHERITED DISORDERS OF HEMOGLOBIN 133 THALASSEMIAS 134…
Acquired hemolytic anemia
CHAPTER 10 Acquired hemolytic anemia DM. Arnold, I. Nazi, JC. Moore, NM. Heddle, JG. Kelton Chapter contents INTRODUCTION 157 CLINICAL AND LABORATORY FEATURES OF HEMOLYTIC ANEMIA 157 MECHANISMS OF HEMOLYSIS…
Abnormalities in leukocyte morphology and number
CHAPTER 16 Abnormalities in leukocyte morphology and number G. Zini Chapter contents NEUTROPHILS 247 Neutropenia 247 Congenital and idiopathic neutropenias 248 Acquired neutropenias 250 Infections associated with neutropenia 250 Drug-induced…
Sideroblastic anemia
CHAPTER 14 Sideroblastic anemia A. May Chapter contents HEREDITARY SIDEROBLASTIC ANEMIA 225 X-linked inheritance 225 ALA synthase 2 defect 225 ABCB7 defect 228 Autosomal recessive sideroblastic anemia 228 Putative deficit…
Natural anticoagulants and thrombophilia
CHAPTER 36 Natural anticoagulants and thrombophilia E. Norström, G. Escolar Chapter contents INTRODUCTION 583 COAGULATION 584 Classic cascade mechanism of coagulation vs. cell-based models of thrombin generation 584 Molecular mechanism…
Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
CHAPTER 21 Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms O. Bock, HH. Kreipe Chapter contents INTRODUCTION 321 THE PHILADELPHIA CHROMOSOME AND BCR-ABL IN CHRONIC MYELOGENOUS LEUKEMIA 322 THE JANUS KINASE…
Aplastic anemia and pure red cell aplasia
CHAPTER 13 Aplastic anemia and pure red cell aplasia EC. Gordon-Smith Chapter contents ACQUIRED APLASTIC ANEMIA 213 Definition and differential diagnosis 213 Etiology 214 Drugs 214 Industrial/domestic chemicals 214 Viruses…
Acquired bleeding disorders
CHAPTER 35 Acquired bleeding disorders DJ. Perry, C. Grove Chapter contents INTRODUCTION 566 PHYSIOLOGICAL DEFICIENCIES 566 Neonates 566 DRUG-INDUCED BLEEDING DISORDERS 566 Heparin 566 Laboratory monitoring 566 Hirudin and bivalirudin…
Transfusion medicine for pathologists
CHAPTER 38 Transfusion medicine for pathologists J. McCullough Chapter contents INTRODUCTION 620 BLOOD SUPPLY SYSTEMS THROUGHOUT THE WORLD 620 Whole blood 620 Blood donor recruitment 620 Plasma 621 WHOLE BLOOD…
