Fixed Drug Eruptions
Fig. 17.1 Adult with multiple FDE due to a Cephalosporin Fig. 17.2 Recurrent localized FDE. Hyperpigmented patch with surrounding violaceous erythema Fig. 17.3 Bulla formation in localized FDE The first…
Chemotherapy and Cutaneous Drug Reactions
Fig. 29.1 Xerosis: significant dryness of the skin of the foot Fig. 29.2 Xerosis: fissures of the hands Dry skin can be attributed to abnormal keratinocyte differentiation, which leads to…
Neutrophilic Dermatoses
Condition Appearance Location Histopathology Associations Sweet’s syndrome Papules, plaques, nodules Head, neck, upper extremity Massive papillary dermal edema, nodular and diffuse neutrophilic infiltration with karyorrhexis Fever, leukocytosis, arthralgias Pyoderma gangrenosum…
Cutaneous Drug Reactions to Anticoagulants
Warfarin-induced skin necrosis Heparin-induced skin necrosis Heparin delayed-type hypersensitivity Incidence 0.01–0.1 % UFH: <3 % LMWH: <0.1 % 7.5 % Onset 90 % day 3–6 Almost all by day…
Medical Therapies and Their Effects on Skin Cancer
Fig. 31.1 Keratotic area on the inner ankle of a patient with lupus erythematosus with a 20-year history of immune suppression with numerous medications. The biopsy showed a squamous cell…
Histopathology of Drug Reactions
and Beth Ruben2 (1) Pathology, Miraca Life Sciences, Irving, TX, USA (2) Dermatology and Pathology, University of California, San Francisco, CA, USA Abstract Cutaneous drug reactions can produce a variety…
Cutaneous Drug Reactions in Patients Infected with Human Immunodeficiency Virus
Fig 37.1 Acute retroviral syndrome includes a diffuse maculopapular eruption in 70–80 % patients (Image content provider: CDC Public Health Image Library, donated by Brian Hill, New Zealand.) Despite the…
Cutaneous Reactions to BRAF Inhibitors
Fig. 32.1 Clinical presentation of the maculopapular rash after 2 weeks of therapy with vemurafenib (Courtesy of Rinderknecht et al. (2013)) Fig. 32.2 Histology of the maculopapular rash demonstrates a…
Cutaneous Reactions to Corticosteroids
Fig. 33.1 Severe tinea corporis of the leg due to trichophytun rubrum. It started out much less prominent, but topical and systemic corticosteroid use caused the leg to swell and…
Tyrosine Kinase Medications and the Skin
Fig. 30.1 Acneiform eruption on the face arising shortly after initiation of EGFR inhibitor therapy Treatment of the folliculitis depends on the severity and any associated symptoms. In asymptomatic, relatively…
