How to Write a Good Scientific Paper
22 How to Write a Good Scientific Paper Charles W. Van Way, III* *Department of Surgery, School of Medicine, University of Missouri, Kansas City, MO, USA. Introduction Simply putting words…
Clinical Science Research
Figure 12.1. Veterans Affairs Cooperative Studies Program (CSP #5) ‘Processes, Structures, and Outcomes of Care in Cardiac Surgery’ conceptual model for quality of care. Within our pluralistic society, the definitions…
Alternatives to Animal Experimentation in Research
Figure 11.1. Toxic test substances cause changes at the molecular level (DNA or protein), which are expressed at the cellular level, which in turn result in target organ toxicity (e.g….
Bioavailability/Bioequivalence: Study Considerations*
16 Bioavailability/Bioequivalence: Study Considerations* Ramana S. Uppoor† * The opinions expressed herein are those of the author and do not necessarily reflect those of the US Food and Drug Administration….
Clinical Pharmacology: Characterisation of a Drug Product*
Example An IND under development for the treatment hypertension was found to inhibit CYP3A4 in vitro. A DDI study should be conducted using a CYP3A4 specific substrate such as midazolam….
Research in Nanomedicine Technologies
Figure 9.1. Schematic depicting the size of various substances. Proteins and other biomolecules such as DNA fall within nanometre range.2 Translational Medicine Translational medicine is an up and coming branch…
Writing a Research Protocol in Pharmacology and Toxicology*
Figure 5.1. Developmental process in the planning for a research protocol. Success of the Research Work Upon completion of the study, the research work should have made a worthwhile contribution…
Nanoparticle-Based Nicotine Vaccine
Fig. 14.1 Schematic of Selecta’s SVP nanoparticle platform SVP nanoparticles are created from polymers [poly(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) (as PLGA-PEG)] that are present in multiple FDA-approved products….
Hapten Design for Anti-addiction Vaccine Development
Fig. 18.1 Major drugs of abuse targets for immunopharmacotherapy 18.1 Drug Target Consideration for Hapten Design Many of the principles of hapten design are generally applicable to any target drug…
B Cell Mechanisms Underlying Vaccine Efficacy Against Drugs of Abuse
Fig. 19.1 Therapeutic vaccines for drug addiction elicit an adaptive immune response against drugs of abuse. The composition of the vaccine is critical for recognition by antigen-presenting cells (APC) and…
