Isoniazid

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Isoniazid

Key Points Isoniazid inhibits the synthesis of mycolic acids, which are the building blocks for the mycobacterial cell wall. Isoniazid is used in combination with other agents to treat active…

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Oxazolidinones

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Oxazolidinones

Key Points Linezolid is the first in a new class of antibacterial agents active against Gram positive bacteria. It has excellent bioavailability and distribution into body tissues, making it particularly…

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Chloramphenicol

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Chloramphenicol

Key Points Chloramphenicol has a broad spectrum of activity but, due to toxicity issues, its use is reserved for severe infections or for topical applications. Chloramphenicol inhibits protein synthesis through…

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Rifamycin Antibacterial Agents

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Rifamycin Antibacterial Agents

Key Points The rifamycins are semisynthetic antibiotics which have broad-spectrum activity. Resistance to the rifamycins arises due to mutations in the rpoB gene, which encodes the β-subunit of RNA polymerase….

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Daptomycin

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Daptomycin

Key Points Daptomycin is approved for the treatment of MRSA-linked complicated skin and skin-structure infections (cSSSIs) and bacteraemia, including right-sided endocarditis. The mode of action is not well understood, but…

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Questions

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Questions

(E. Marchi and L. Montecchi, US Patent 4341785, 27 July 1982.) 5. The emergence of MDR-TB is becoming a significant clinical problem. Describe the mechanism by which bacteria become resistant…

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Questions

Aug 27, 2016 by in GENERAL & FAMILY MEDICINE Comments Off on Questions

html xmlns=”http://www.w3.org/1999/xhtml”> Questions 1. In Figure 1.1.5, if the pink colour represents guanine, deduce the colours of the other bases. 2. In Figure 1.1.6, what will be the next amino…

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Mental and Behavioral Health

Aug 27, 2016 by in PUBLIC HEALTH AND EPIDEMIOLOGY Comments Off on Mental and Behavioral Health

21 Mental and Behavioral Health Elizabeth C. Katz, Eugene M. Dunne, Samantha Lookatch, Joshua S. Camins Chapter Outline I. MENTAL HEALTH/BEHAVIORAL DISORDERS AND SUICIDE  A. Definitions  B. Epidemiology  C. Costs  II. RISK AND PROTECTIVE FACTORS …

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