Thyroid Disorders
Thyroid Disorders Jacqueline Jonklaas and Robert L. Talbert KEY CONCEPTS Advances in the understanding of the structure and metabolism of thyroid hormones, and the molecular biology of thyroid…
The Arrhythmias
The Arrhythmias Cynthia A. Sanoski and Jerry L. Bauman KEY CONCEPTS The use of antiarrhythmic drugs (AADs) in the United States has declined because of major trials that…
Venous Thromboembolism
Venous Thromboembolism Daniel M. Witt and Nathan P. Clark KEY CONCEPTS The risk of venous thromboembolism (VTE) is related to several easily identifiable factors, including age, major surgery…
Lower Respiratory Tract Infections
Lower Respiratory Tract Infections Martha G. Blackford, Mark L. Glover, and Michael D. Reed KEY CONCEPTS Respiratory infections remain the major cause of morbidity from acute illness in…
Skin and Soft-Tissue Infections
Skin and Soft-Tissue Infections Douglas N. Fish and Susan L. Pendland KEY CONCEPTS Folliculitis, furuncles (boils), and carbuncles begin around hair follicles and are caused most often by…
Pregnancy and Lactation: Therapeutic Considerations
KEY CONCEPTS Complex physiology surrounds the process of fertilization and pregnancy progression. Drug characteristics and physiologic changes modify drug pharmacokinetics during pregnancy, including changes in absorption, protein binding,…
Drug Therapy Individualization for Patients with Chronic Kidney Disease
KEY CONCEPTS Chronic kidney disease (CKD) results in minimal alterations in the absorption or bioavailability of most drugs. The volume of distribution (VD) of many drugs is increased…
Erectile Dysfunction
Erectile Dysfunction Mary Lee KEY CONCEPTS The incidence of erectile dysfunction is low in men younger than 40 years of age. The incidence increases as men age, likely…
Disorders of Sodium and Water Homeostasis
Disorders of Sodium and Water Homeostasis Katherine Hammond Chessman and Gary R. Matzke KEY CONCEPTS Blood volume and plasma osmolality are tightly regulated in the human body because…
