Hepatocellular Carcinoma and Variants Joseph Misdraji, MD Laura Webb Lamps, MD Key Facts Etiology/Pathogenesis Chronic viral hepatitis is leading cause of HCC worldwide 70-90% of HCC arises in cirrhosis Clinical…
von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD Key Facts Terminology Developmental malformation resulting from aberrant construction/remodeling of embryonic bile ducts Etiology/Pathogenesis Most often sporadic; also associated with several fibropolycystic…
Peribiliary Hamartoma (Bile Duct Adenoma) Sanjay Kakar, MD Key Facts Terminology Historically called “bile duct adenoma” but shown to have phenotype of peribiliary glands rather than bile ducts Clinical Issues…
Focal Nodular Hyperplasia Matthew M. Yeh, MD, PhD Key Facts Terminology Benign tumor-like lesion of liver caused by hyperplastic response to localized vascular abnormality Clinical Issues Mostly incidental finding on…
Hepatic Adenoma Matthew M. Yeh, MD, PhD Key Facts Etiology/Pathogenesis Almost always associated with oral contraceptive or long-term steroid use May regress after withdrawal of oral contraceptives Clinical Issues Typically…
Chronic Rejection Matthew M. Yeh, MD, PhD Key Facts Microscopic Pathology Atypical bile duct epithelium resembling dysplasia Centrizonal perivenular hepatocyte dropout Loss of interlobular bile duct Foam cell arteriopathy Luminal…
Acute Cellular Rejection Lisa Yerian, MD Key Facts Terminology Immune-mediated inflammation and injury of liver allograft due to genetic mismatch Etiology/Pathogenesis Inflammatory cells in portal tracts and centrilobular, perivenular areas…
Nodular Regenerative Hyperplasia Sanjay Kakar, MD Key Facts Etiology/Pathogenesis NRH results from changes in hepatic blood flow resulting from obliteration of small portal vein radicles Clinical Issues Symptomatic NRH clinically…
Amyloidosis Sanjay Kakar, MD Key Facts Etiology/Pathogenesis Liver involvement may be seen in AL, AA, and hereditary amyloidosis Microscopic Pathology Sinusoidal pattern is more common in AL amyloidosis and vascular…
Veno-occlusive Disease Sanjay Kakar, MD Key Facts Etiology/Pathogenesis Stem cell transplantation and high-dose chemotherapy Sinusoidal endothelial cell injury is important initial event Clinical Issues Hyperbilirubinemia, weight gain, and painful hepatomegaly…
