Acute Cellular Rejection



Acute Cellular Rejection


Lisa Yerian, MD









H&E section of acute rejection shows a mixed portal inflammatory cell infiltrate composed of activatedappearing lymphocytes, histiocytes, eosinophils, and other inflammatory cells.






H&E stain demonstrates endotheliitis image of a portal vein branch and bile duct damage image. The portal tract also contains a mixed inflammatory cell infiltrate.


TERMINOLOGY


Abbreviations



  • Acute cellular rejection (ACR)


Synonyms



  • Acute rejection


Definitions



  • Immune-mediated inflammation and injury of liver allograft due to genetic mismatch


ETIOLOGY/PATHOGENESIS


Immune-mediated Inflammatory Process



  • Recipient immune system recognizes donor antigens in liver allograft as foreign


  • Inflammatory cells in portal tracts and centrilobular, perivenular areas cause damage to biliary epithelium and endothelial cells

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Acute Cellular Rejection
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