Amyloidosis
Amyloidosis A. Brad Farris, III, MD Key Facts Terminology Accumulation of any 1 of > 20 amyloid proteins, characterized by apple-green birefringence after Congo red stain due to β-pleated sheet…
Ovary, Mass: Diagnosis
Ovary, Mass: Diagnosis A typical endometrioma, or “chocolate cyst,” of the ovary has a flat velvety lining and is filled with a thick, brown fluid. Carcinomas arising in these lesions…
Collapsing Glomerulopathy
Collapsing Glomerulopathy A. Brad Farris, III, MD Key Facts Etiology/Pathogenesis Podocyte proliferation and dedifferentiation are thought to play a role Idiopathic most common form Heterogeneous secondary forms Infection: HIV, parvovirus…
Renal Artery Stenosis
Renal Artery Stenosis A. Brad Farris, III, MD Key Facts Etiology/Pathogenesis Renal artery stenosis from variety of potential causes results in ischemic atrophy Atherosclerosis with atheromatous plaques is one of…
Hypertensive Renovascular Disease
Hypertensive Renovascular Disease A. Brad Farris, III, MD Key Facts Terminology Vascular and glomerular disease 2° to hypertension Clinical Issues ˜ 30% of American adults have hypertension 95% due to…
Drug-induced Acute Interstitial Nephritis
Drug-induced Acute Interstitial Nephritis Neeraja Kambham, MD Key Facts Terminology Acute tubulointerstitial inflammation due to allergic reaction to a drug Etiology/Pathogenesis T-cell-mediated hypersensitivity reaction Idiosyncratic reaction, not dose dependent Clinical…
Fibrillary Glomerulopathy
Fibrillary Glomerulopathy Anthony Chang, MD Key Facts Clinical Issues Rare: < 1% of native kidney biopsies Associated with malignancy, dysproteinemia, and autoimmune disease Proteinuria (100%) Hematuria (˜ 50%) 40-50% progress…
Multilocular Cystic Nephroma
Multilocular Cystic Nephroma Aleksandr Vasilyev, MD, PhD Key Facts Terminology Multilocular cystic nephroma (MCN) Cystic nephroma (CN), multilocular cyst Etiology/Pathogenesis Relationship to sex hormones is suggested Clinical Issues Female:male ratio…
Oculocerebrorenal Syndrome of Lowe
Oculocerebrorenal Syndrome of Lowe Ami Bhalodia, MD Key Facts Terminology Oculocerebrorenal syndrome (OCRL) Etiology/Pathogenesis Inherited mutation caused by OCRL1 gene mutation Affects protein trafficking and cellular metabolism Clinical Issues X-linked…
Polyarteritis Nodosa
Polyarteritis Nodosa Surya V. Seshan, MD Key Facts Terminology Necrotizing inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or venules Clinical Issues HBV association in…
