Warty Dyskeratoma

 Round to slightly oval nucleus with pink cytoplasm

• Grains
image Raisinoid nuclei with pink cytoplasm

• Minimal to no cytologic atypia

Top Differential Diagnoses

• Darier disease
image Histologically similar

image Clinically different

– Multiple lesions in seborrheic distribution

• Acantholytic dyskeratotic acanthoma
image Similar to WD
– Both have acantholysis and dyskeratosis

– Both are usually clinically solitary lesions

image Unlike WD
– Not cup-shaped or associated with hair follicles

– Flat-based lesion

• Acantholytic squamous cell carcinoma
image Infiltrative

image Cytologic atypia

image Atypical mitoses

Warty Dyskeratoma: Low-Power Architecture
This is a low-power view of a warty dyskeratoma, a cup-shaped lesion. There is hyperkeratosis and parakeratosis above central acantholytic dyskeratosis image with villi at the base image.

Warty Dyskeratoma: Acantholytic Dyskeratosis
Acantholysis and dyskeratosis within the hyperplastic epithelial cup are seen here.

Acantholytic Dyskeratosis: Prominent Grains
Higher magnification shows numerous grains image below hyperkeratosis.

Acantholytic Dyskeratosis: Prominent Corp Ronds
A high-power view shows the central acantholytic dyskeratosis in a warty dyskeratoma. There are corp ronds (central round to slightly oval shrunken nuclei with surrounding pink cytoplasm) image.



• Warty dyskeratoma (WD)


• Cup-shaped epidermal proliferation

• Acantholysis is present

• Dyskeratosis (corp ronds and grains) is present



• Germline mutations in ATP2A2 not described (as are seen in Darier disease)

• Human papilloma virus infection has not been associated with WD

Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Warty Dyskeratoma

Full access? Get Clinical Tree

Get Clinical Tree app for offline access
%d bloggers like this: