UNSTABLE HEMOGLOBINS Amino acid substitutions that reduce solubility or increase susceptibility to oxidation result in unstable hemoglobins that precipitate, forming inclusion bodies injurious to the RBC membrane. Representative mutations are…
462e Muscular Dystrophies and Other Muscle Diseases Anthony A. Amato, Robert H. Brown, Jr. Skeletal muscle diseases, or myopathies, are disorders with structural changes or functional impairment of muscle….
114 Bladder and Renal Cell Carcinomas Howard I. Scher, Jonathan E. Rosenberg, Robert J. Motzer BLADDER CANCER Transitional cell epithelium lines the urinary tract from the renal pelvis to…
PART 16: Endocrinology and Metabolism SECTION 1 ENDOCRINOLOGY 399 Approach to the Patient with Endocrine Disorders J. Larry Jameson The management of endocrine disorders requires a broad understanding of…
456 Diseases of the Spinal Cord Stephen L. Hauser, Allan H. Ropper Diseases of the spinal cord are frequently devastating. They produce quadriplegia, paraplegia, and sensory deficits far beyond…
452 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr. AMYOTROPHIC LATERAL SCLEROSIS Amyotrophic lateral sclerosis (ALS) is the most common form of progressive motor neuron…
84 The Practice of Genetics in Clinical Medicine Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt APPLICATIONS OF MOLECULAR GENETICS IN CLINICAL MEDICINE Genetic testing for inherited abnormalities associated…
PART 6: Nutrition and Weight Loss 95e Nutrient Requirements and Dietary Assessment Johanna Dwyer Nutrients are substances that are not synthesized in sufficient amounts in the body and…
FIGURE 103e-1 Gompertzian tumor growth. The growth fraction of a tumor declines exponentially over time (top). The growth rate of a tumor peaks before it is clinically detectable (middle). Tumor size…
336 Dialysis in the Treatment of Renal Failure Kathleen D. Liu, Glenn M. Chertow Dialysis may be required for the treatment of either acute or chronic kidney disease. The use of…
