Basicmedical Key

Burkitt Lymphoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Clinical Issues Median age in adult group is 30 years In the West, BL presents as abdominal mass BL may also…

EBV+ Diffuse Large B-cell Lymphoma of the Elderly Tarlq Muzzzafar, MBBS Key Facts Terminology DLBCL infected by EBV occurring in patients > 50 years old without history of immunodeficiency or…

Lymphadenopathy Secondary to Drug-induced Hypersensitivity Syndrome Tariq Muzzafar, MBBS Key Facts Terminology DIHS is idiosyncratic host reaction to drug involving T-cell/macrophage activation and cytokine release Criteria for diagnosis of DIHS…

Mantle Cell Lymphoma, Blastoid Variant C. Cameron Yin, MD, PhD Key Facts Terminology Highly aggressive subtype of mantle cell lymphoma composed of cells that resemble lymphoblasts (classic variant) or are…

Rheumatoid Arthritis-related Lymphadenopathy L. Jeffrey Medeiros, MD Key Facts Terminology Lymphadenopathy accompanying rheumatoid arthritis (RA) Etiology/Pathogenesis Smoking is risk factor Infectious agent may act as antigenic trigger of RA Genetic…

Hemophagocytic Lymphohistiocytosis Sa A. Wang, MD Key Facts Terminology Cytokine dysfunction, resulting in activation of T lymphocytes and macrophages Leads to systemic symptoms and organ damage Etiology/Pathogenesis Inherited genetic or…

Mantle Cell Lymphoma C Cameron Yin, MD, PhD Key Facts Terminology Clinically aggressive B-cell lymphoma associated with t(11;14)(q13;q32) and Cyclin-D1 overexpression Clinical Issues Elderly people; male predominance Most patients present…

Multicentric Castleman Disease Pei Lin, MD Key Facts Terminology Systemic lymphoproliferative disease occurs in patients with immunodeficiency or immune dysregulation and is usually associated with human herpesvirus type 8 (HHV8)…

Lipid-associated Lymphadenopathy Tariq Muzzafar, MBBS Key Facts Terminology Lymphadenopathy characterized by accumulation of endogenous or exogenous lipids Etiology/Pathogenesis Endogenous Diabetes mellitus, hyperlipidemia, hepatobiliary diseases Exogenous Total parenteral nutrition Mineral oil…

Unicentric Plasma Cell Variant Castleman Disease Pei Lin, MD Key Facts Terminology Histologically distinctive reaction pattern in lymph node characterized by Marked interfollicular plasmacytosis Regressive (hyaline-vascular) changes in small subset…