Mantle Cell Lymphoma

Mantle Cell Lymphoma

C Cameron Yin, MD, PhD

Mantle cell lymphoma (MCL) with a nodular and diffuse pattern associated with hyalinized blood vessels. Hyalinized blood vessels are common in MCL.

Cyclin-D1 immunostain shows nuclear expression in the cells of mantle cell lymphoma. As demonstrated here, the nuclei often show cell to cell variation in the intensity of Cyclin-D1 expression.



  • Mantle cell lymphoma (MCL)


  • Centrocytic lymphoma

  • Lymphocytic lymphoma, intermediate grade of differentiation

  • Intermediate lymphocytic lymphoma


  • Clinically aggressive B-cell lymphoma usually composed of monomorphic small to medium-sized cells and associated with t(11;14)/CCND-1-IgH



  • Juxtaposes CCND-1 at 11q13 with IgH at 14q32 and results in Cyclin-D1 overexpression, Rb phosphorylation, and release of E2F

  • Facilitates cell cycle progression from G1 to S phase



  • Median age: 6th-7th decades; male predominance

  • Most patients present with Ann Arbor clinical stage III/IV; B symptoms in 40-50%

  • Lymphadenopathy, generalized

  • Extranodal sites are common, particularly GI tract, bone marrow, spleen, peripheral blood


  • Aggressive chemotherapy ± stem cell transplantation

  • HyperCVAD chemotherapy regimen used at many medical centers

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Mantle Cell Lymphoma

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