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Podocin Deficiency Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Clinical Issues Proteinuria, may be nephrotic range 90% of familial cases progress to ESRD within ˜ 6 years 35%…

Thin Basement Membrane Disease Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Clinical Issues Presents with persistent microscopic hematuria Autosomal dominant inheritance 1-5% of population Microscopic Pathology Minimal changes…

Lyme Disease Membranoproliferative Glomerulonephritis Neeraja Kambham, MD Key Facts Terminology Immunological renal manifestation of MPGN, type 1 due to Borrelia burgdorferi infection Clinical Issues High level of clinical suspicion is…

Hepatic Glomerulosclerosis Robert B. Colvin, MD Key Facts Terminology Glomerular disease caused by portal hypertension Clinical Issues Present in ˜ 60% of cirrhotics Asymptomatic hematuria, proteinuria Remission with correction of…

Pamidronate-induced Collapsing FSGS A. Brad Farris, III, MD Key Facts Terminology Collapsing FSGS secondary to use of pamidronate, a bisphosphonate inhibitor of bone resorption Clinical Issues HIV-negative patients with nephrotic…

Introduction to Diseases with Monoclonal Immunoglobulin Deposits Robert B. Colvin, MD Diagnosis of diseases with monoclonal immunoglobulin deposits &/or substructure by EM is facilitated by following the path in this…

Graft-vs.-Host Glomerulopathies Anthony Chang, MD Key Facts Terminology Graft-vs.-host disease (GVHD) glomerulopathy Glomerular injury in setting of hematopoietic cell transplantation and GVHD Clinical Issues Proteinuria, nephrotic range Microscopic Pathology 3…

Drug-induced Minimal Change Disease Anthony Chang, MD Key Facts Etiology/Pathogenesis Common offending agents Nonsteroidal anti-inflammatory drugs (NSAIDs) Cyclooxygenase 2 inhibitors Pamidronate Interferon-α and interferon-β Rifampin Clinical Issues Nephrotic syndrome Treatment…