Thin Basement Membrane Disease

Thin Basement Membrane Disease

Helen Liapis, MD

Joseph Gaut, MD, PhD

This PAS stained slide from a woman with thin basement membrane disease (TBMD) shows a normal glomerulus, typical of TBMD by light microscopy. The GBM averaged 230 nm by electron microscopy.

Electron microscopy in TBMD reveals a diffusely thin but otherwise normal GBM of < 200 nm (normal is 320 ± 50 nm in females, 370 ± 50 nm in males). Morphometry is recommended to assess the thickness of the GBM.



  • Thin basement membrane disease (TBMD)


  • Benign familial hematuria (BFH)


  • Autosomal dominant disorder presenting with asymptomatic microscopic hematuria characterized by diffuse GBM thinning



Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Thin Basement Membrane Disease

Full access? Get Clinical Tree

Get Clinical Tree app for offline access