Focal Segmental Glomerulosclerosis, Secondary A. Brad Farris, III, MD Key Facts Terminology FSGS secondary to imbalance of glomerula-functional capacity and demand Etiology/Pathogenesis Adaptive structural-functional response Reduced nephron mass: Oligomeganephronia, reflux…
Type III Hyperlipoproteinemia Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis APOE2 homozygotes Autosomal recessive Clinical Issues Males more commonly affected Nephrotic syndrome Premature vascular disease Palmar and…
Congenital Nephrotic Syndrome of the Finnish Type Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Terminology Finnish nephropathy (FN) Occurs in neonates up to 3 months of age and…
Classification of Tubulointerstitial Diseases Robert B. Colvin, MD Acute interstitial nephritis was originally described in 1898 by William Councilman as a systemic response to certain extrarenal infections (here an untreated…
Gaucher Glomerulopathy A. Brad Farris, III, MD Key Facts Terminology Gaucher cells accumulate in renal parenchyma Etiology/Pathogenesis Glucosylceramide accumulation 2° to ↓ glucosylceramidase activity Clinical Issues Proteinuria, hematuria, nephrotic syndrome…
IgA Acute Glomerulonephritis Associated with S. Aureus Robert B. Colvin, MD Key Facts Etiology/Pathogenesis Staphylococcus aureus, coagulase positive, often MRSA Increased risk with diabetes mellitus, neoplasia, old age Clinical Issues…
Lipoprotein Glomerulopathy Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis APOE gene mutations Clinical Issues Majority of cases reported in patients of Asian ancestry Microscopic Pathology Glomerular intracapillary…
Fibronectin Glomerulopathy Neeraja Kambham, MD Key Facts Terminology Nonimmune lobular glomerulopathy with massive mesangial and subendothelial fibronectin deposits Etiology/Pathogenesis Autosomal dominant inheritance Mutations in fibronectin FN1 gene documented recently in…
Nail-Patella Synorome Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis LMX1B mutations Clinical Issues Iliac horns are pathognomonic (70% of cases) Absent, hypoplastic, or dystrophic nails Small, irregularly…
Focal Segmental Glomerulosclerosis Classification A. Brad Farris, III, MD Light microscopy of a case of collapsing FSGS shows a glomerulus with areas of sclerosis (silver stain). Immunofluorescence for C3 shows…
