Nail-Patella Synorome

Nail-Patella Synorome

Helen Liapis, MD

Joseph Gaut, MD, PhD

In nail-patella syndrome (NPS), glomeruli typically have minimal changes by light microscopy. The glomerulus illustrated has minimal mesangial hypercellularity.

In NPS, phosphotungstic acid stain reveals electron-dense bundles of collagen fibrils image in the GBM by electron microscopy. This stain helps visualize bundles and their ˜ 60 nm periodicity image.



  • Nail-patella syndrome (NPS)


  • Hereditary onychoosteodysplasia (HOOD) syndrome


  • Inherited syndrome presenting with nail, skeletal abnormalities, and proteinuria secondary to mutations in LMX1B gene

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Nail-Patella Synorome
Premium Wordpress Themes by UFO Themes
%d bloggers like this: