Metastatic Melanoma
Metastatic Melanoma Elizabeth A. Montgomery, MD Key Facts Terminology Spread of malignant melanoma to gastrointestinal tract In contrast to rare primary melanomas that typically involve esophagus and anus Clinical Issues…
Hamartomatous Polyps, Peutz-Jeghers
Hamartomatous Polyps, Peutz-Jeghers Amitabh Srivastava, MD Key Facts Terminology Peutz-Jeghers polyposis syndrome is characterized by mucocutaneous pigmentation, hamartomatous polyposis, and increased risk of cancer Etiology/Pathogenesis Germline mutation in LKB1/STK11 gene…
Hamartomatous Polyps, Juvenile
Hamartomatous Polyps, Juvenile Amitabh Srivastava, MD Key Facts Terminology Hamartomatous polyp that may occur sporadically or as part of polyposis syndrome Etiology/Pathogenesis Germline mutations in SMAD4 or BMPR1A present in…
Colchicine Effect
Colchicine Effect Elizabeth A. Montgomery, MD Key Facts Terminology GI symptoms associated with mitotic arrest restricted to proliferative compartment of mucosa Best seen in small bowel and gastric antrum Clinical…
Paclitaxel (Taxol) Effect
Paclitaxel (Taxol) Effect Elizabeth A. Montgomery, MD Key Facts Terminology Pattern of mitotic arrest and apoptosis of the gastrointestinal tract mucosa associated with administration of paclitaxel (Taxol) Clinical Issues Excellent…
Paget Disease
Paget Disease Scott R. Owens, MD Key Facts Terminology Primary Perianal Paget disease not associated with underlying rectal or anal neoplasm Secondary Perianal Paget disease associated with adenocarcinoma of distal…
Condyloma, Anus
Condyloma, Anus Scott R. Owens, MD Key Facts Etiology/Pathogenesis Sexually transmitted disease HPV serotypes 6, 11 most common in anal condylomata Clinical Issues Increasing incidence (˜ 50% over past several…
Inflammatory Bowel Disease-Associated Neoplasia
Inflammatory Bowel Disease-Associated Neoplasia Julianne K. Purdy, MD Key Facts Macroscopic Features Polypoid dysplastic lesion/DALM Adenoma-like: Endoscopically resectable, dome-shaped, sharp borders Non-adenoma-like: Not endoscopically resectable, sessile/plaque-like, indistinct margins Microscopic Pathology…
Hemorrhoids
Hemorrhoids Julianne K. Purdy, MD Key Facts Terminology Hemorrhoids are normal submucosal vascular beds Hemorrhoidal disease when vessels dilate and symptoms develop Clinical Issues Internal hemorrhoids: Painless rectal bleeding External…
Carcinoid Tumor, Colon
Carcinoid Tumor, Colon Scott R. Owens, MD Key Facts Clinical Issues More commonly occurs in rectum than in remainder of colon Most are asymptomatic Local excision sufficient for small tumors…
