Condyloma, Anus
Scott R. Owens, MD
Key Facts
Etiology/Pathogenesis
Sexually transmitted disease
HPV serotypes 6, 11 most common in anal condylomata
Clinical Issues
Increasing incidence (˜ 50% over past several decades)
Most common in adults; can occur at any age
Can be associated with other HPV infection-related pathology
May affect anal transition zone or perianal skin
Microscopic Pathology
Characteristic cells with viral effect (koilocytes) seen histologically
Reactive epithelial atypia possible in inflamed lesions
Squamous epithelium matures normally
 Hematoxylin & eosin shows a low-power view of an anal condyloma. Note the papillomatous growth pattern and attachment  to perianal skin. |
 Hematoxylin & eosin shows several koilocytes  indicative of HPV infection. Note the characteristic perinuclear halos surrounding irregularly contoured nuclei  . |
TERMINOLOGY
Synonyms
Anogenital wart
Definitions
Squamous papilloma caused by infection with human papillomavirus (HPV)
ETIOLOGY/PATHOGENESIS
Infectious Agents
HPV
Sexually transmitted disease
Most frequently seen in patients who engage in anal intercourse
Several HPV serotypes commonly found (1, 2, 6, 7, 10, 11, 16, 18)
6, 11 most common in anal condylomata
16, 18 associated with squamous dysplasia/anal intraepithelial neoplasia
CLINICAL ISSUES
