Fig. 15.1 Representative DNA nanostructures. (a) Representative DNA double crossover, known as DAE (double crossover in antiparallel with even number of helical half turns between crossovers) (Lin et al. 2009;…
Fig. 17.1 Reactogenicity of adjuvant-treated skin. The low back skin of BALB/c mice was treated with a laser defined in 17.3.2.1, TLR agonist-based adjuvants (MPL, R837, CpG), depot adjuvants (alum,…
Fig. 13.1 The production of the disrupted adenovirus vaccine dAd5GNE. Recombinant, E1‾E3‾ replication-incompetent adenovirus serotype 5 is disrupted by detergent and heat, and the disassociated capsid proteins (fiber, hexon, and…
Fig. 11.1 Long-term blockade of cocaine-primed reinstatement responding. CocH vector-treated rats (N = 14) made significantly fewer responses (# p < 0.05) on the lever previously paired with cocaine than control rats (N = 26) following…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_21 21. Ethical Considerations of Biologics to Treat Substance Use Disorders Ivan D. Montoya1 (1) Division of Therapeutics and Medical Consequences of Drug…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_1 1. Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes Phil Skolnick1 (1) Division of Pharmacotherapies and Medical…
, Berma M. Kinsey3, 4, Reetakshi Arora4, 5, Muthu Ramakrishnan3, 4 and Thomas R. Kosten6, 7 (1) Departments of Medicine, Pathology and Immunology, and Molecular Virology and Microbiology, Center for Translational Research in Inflammatory Diseases, Baylor…
Enzyme/antibody Km (μM) Kcat 3B9 490 0.11 min−1 15A10 220 2.3 min−1 BChE 38 1.2 min−1 Bacterial cocaine esterase 0.640 7.8 s−1 The catalytic antibody that received the most attention…
Fig. 5.1 Pooled antibody titer levels measured by ELISA on sera samples obtained from weeks 2 through 21 after the initial vaccination with SMA-TT with alum alone as adjuvant are…
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_3 3. Vaccines for Treating Cocaine Use Disorders Coreen B. Domingo1, 2 , Daryl Shorter1, 2 and Thomas R. Kosten1, 2 (1) Michael E DeBakey Veterans Affairs…
