Skin Vaccination Against Nicotine Addiction
Fig. 17.1 Reactogenicity of adjuvant-treated skin. The low back skin of BALB/c mice was treated with a laser defined in 17.3.2.1, TLR agonist-based adjuvants (MPL, R837, CpG), depot adjuvants (alum,…
Exploration of DNA Nanostructures for Rational Design of Vaccines
Fig. 15.1 Representative DNA nanostructures. (a) Representative DNA double crossover, known as DAE (double crossover in antiparallel with even number of helical half turns between crossovers) (Lin et al. 2009;…
Viral Gene Transfer of Enzymes
Fig. 11.1 Long-term blockade of cocaine-primed reinstatement responding. CocH vector-treated rats (N = 14) made significantly fewer responses (# p < 0.05) on the lever previously paired with cocaine than control rats (N = 26) following…
Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders
Fig. 13.1 The production of the disrupted adenovirus vaccine dAd5GNE. Recombinant, E1‾E3‾ replication-incompetent adenovirus serotype 5 is disrupted by detergent and heat, and the disassociated capsid proteins (fiber, hexon, and…
Ethical Considerations of Biologics to Treat Substance Use Disorders
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_21 21. Ethical Considerations of Biologics to Treat Substance Use Disorders Ivan D. Montoya1 (1) Division of Therapeutics and Medical Consequences of Drug…
Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_1 1. Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes Phil Skolnick1 (1) Division of Pharmacotherapies and Medical…
Adjuvants for Substance Abuse Vaccines
, Berma M. Kinsey3, 4, Reetakshi Arora4, 5, Muthu Ramakrishnan3, 4 and Thomas R. Kosten6, 7 (1) Departments of Medicine, Pathology and Immunology, and Molecular Virology and Microbiology, Center for Translational Research in Inflammatory Diseases, Baylor…
Vaccines for Methamphetamine Use Disorder
Fig. 5.1 Pooled antibody titer levels measured by ELISA on sera samples obtained from weeks 2 through 21 after the initial vaccination with SMA-TT with alum alone as adjuvant are…
Anti-cocaine Monoclonal Antibodies
Enzyme/antibody Km (μM) Kcat 3B9 490 0.11 min−1 15A10 220 2.3 min−1 BChE 38 1.2 min−1 Bacterial cocaine esterase 0.640 7.8 s−1 The catalytic antibody that received the most attention…
Monoclonal Antibodies
© Springer International Publishing Switzerland 2016Ivan D. Montoya (ed.)Biologics to Treat Substance Use Disorders10.1007/978-3-319-23150-1_7 7. Monoclonal Antibodies S. Michael Owens1 (1) Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little…
