Lymphoepithelioma-Like Carcinoma of Skin

Lymphoepithelioma-Like Carcinoma of the Skin
High magnification of lymphoepithelioma-like carcinoma of the skin (LELCS) shows a prominent lymphohistiocytic infiltrate obscuring a background of large, undifferentiated epithelioid-appearing cells

Low Magnification of LELCS
This is an example of LELCS at low magnification showing large, irregular epithelial islands surrounded by a very dense inflammatory infiltrate.

High Magnification of LELCS
LELCS at high magnification shows islands of atypical basaloid-appearing epithelial cells surrounded by a dense mixed acute and chronic inflammatory infiltrate.

Immunohistochemistry for p63 in LELCS
Immunohistochemical stain for p63 shows diffuse nuclear staining of the epithelial cells, which are in islands surrounded by inflammatory cells.

TERMINOLOGY

Abbreviations

• Lymphoepithelioma-like carcinoma of skin (LELCS)

Definitions

• Poorly differentiated carcinoma, most likely variant of squamous cell carcinoma (SCC), with prominent inflammatory infiltrate mimicking lymphoepithelioma-like carcinoma of nasopharynx

ETIOLOGY/PATHOGENESIS

Unknown

• No proven relationship with Epstein-Barr virus (EBV), unlike nasopharyngeal lymphoepitheliomas

CLINICAL ISSUES

Epidemiology

• Incidence

Extremely rare variant of SCC; < 70 cases reported to date

• Age

Typically occurs in elderly patients

• Sex

M > F

Site

• Most common in head and neck region

Presentation

• Nodular erythematous lesion

Treatment

• Surgical approaches

Complete excision is definitive treatment, similar to invasive SCC

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Tags: Diagnostic Pathology: Neoplastic Dermatopathology

Apr 24, 2017 | Posted by admin in PATHOLOGY & LABORATORY MEDICINE | Comments Off

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Lymphoepithelioma-Like Carcinoma of Skin