Lymphoepithelioma-Like Carcinoma of the Skin High magnification of lymphoepithelioma-like carcinoma of the skin (LELCS) shows a prominent lymphohistiocytic infiltrate obscuring a background of large, undifferentiated epithelioid-appearing cells .
Low Magnification of LELCS This is an example of LELCS at low magnification showing large, irregular epithelial islands surrounded by a very dense inflammatory infiltrate.
High Magnification of LELCS LELCS at high magnification shows islands of atypical basaloid-appearing epithelial cells surrounded by a dense mixed acute and chronic inflammatory infiltrate.
Immunohistochemistry for p63 in LELCS Immunohistochemical stain for p63 shows diffuse nuclear staining of the epithelial cells, which are in islands surrounded by inflammatory cells.
TERMINOLOGY
Abbreviations
• Lymphoepithelioma-like carcinoma of skin (LELCS)
Definitions
• Poorly differentiated carcinoma, most likely variant of squamous cell carcinoma (SCC), with prominent inflammatory infiltrate mimicking lymphoepithelioma-like carcinoma of nasopharynx
ETIOLOGY/PATHOGENESIS
Unknown
• No proven relationship with Epstein-Barr virus (EBV), unlike nasopharyngeal lymphoepitheliomas
CLINICAL ISSUES
Epidemiology
• Incidence
Extremely rare variant of SCC; < 70 cases reported to date
• Age
Typically occurs in elderly patients
• Sex
M > F
Site
• Most common in head and neck region
Presentation
• Nodular erythematous lesion
Treatment
• Surgical approaches
Complete excision is definitive treatment, similar to invasive SCC
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surrounded by a dense mixed acute and chronic inflammatory infiltrate.
of the epithelial cells, which are in islands surrounded by inflammatory cells.
