Presence of keratocysts allows for distinction (absent in eccrine carcinoma)
• Adenoid cystic carcinoma
Cribriform architecture allows distinction (generally absent in eccrine carcinoma)
• Infiltrative basal cell carcinoma
Lacks true lumen formation
– Typically negative for EMA and CEA
Often has epidermal attachments
May have other basal cell carcinoma subtypes
Eccrine Carcinoma With Deep Invasion Eccrine carcinoma is a dermal-based tumor composed of infiltrating ducts/glands associated with a sclerotic stroma. The tumor is often deeply infiltrative, with invasion into the deep dermis and subcutaneous adipose tissue in most cases.
Eccrine Carcinoma With Subcutaneous Invasion Eccrine carcinoma is very infiltrative and often extends into the underlying subcutaneous fat, as in this case.
Eccrine Carcinoma at Higher Magnification Higher magnification of the infiltrative ducts shows significant atypia, with nuclear hyperchromasia, crowding, and a few mitotic figures .
Eccrine Carcinoma With Perineural Invasion Perineural invasion is a common and expected finding in many eccrine carcinomas.