Haphazard arrangement
Thin fascicles rather than solid growth pattern
No atypia
No mitoses
No necrosis
Immunohistochemistry (+) for muscle markers
Top Differential Diagnoses
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Cutaneous leiomyoma (pilar leiomyoma)
Occurs in adults
Different anatomic distribution
Lobules of mature smooth muscle
•
Leiomyosarcoma
Adults
Deeply infiltrative dermal and subcutaneous tumor
Cytologic atypia
Mitotic activity
•
Neurofibroma
Wavy nuclei
Myxocollagenous stroma
S100(+)
•
Normal skin from special sites
Nipple and genital skin
TERMINOLOGY
Synonyms
•
Smooth muscle hamartoma