Symmetric and well circumscribed Often shows dumbbell-like appearance at low power Cells lack prominent cytologic atypia, mitotic activity, and necrosis • Atypical cellular blue nevus Shows overlapping features with cellular blue…
Small, Nevoid AppearanceNevoid melanoma is deceptively symmetrical, mimicking an intradermal nevus on low-power examination. The only clue is hypercellularity (blue appearance) and lack of maturation, which should invoke a closer…
Port-wine stain usually involving extremity Underlying venous and lymphatic malformations Limb overgrowth with hypertrophy of soft tissue and bone • Blue rubber bleb nevus syndrome Multiple blue-colored, rubbery hemangiomas of skin…
Consumptive coagulopathy Thrombocytopenia Highest risk for coagulopathy in retroperitoneal and intrathoracic tumors, but also seen in association with large cutaneous tumors • Rare regional lymph node metastases • No distant metastases reported…
Most arise at dermal-subcutaneous interface • Also lower extremity, trunk, head, and neck • Painless, slow-growing mass or plaque • Treatment: Wide surgical excision with negative margins • Local recurrence in up to 40%…
ITAN ClinicalClinically, an inverted type A nevus (ITAN) is compared to other pigmented papules. ITAN has an eccentrically placed dark papule upon an evenly pigmented flat area. The lesional borders…
Histiocytosis X Eosinophilic granuloma • Defined as clonal proliferation of Langerhans cells Clinical Issues • Newborns and infants usually present with limited skin or bone lesions • Erythematous, crusted, vesiculopustular rash • Common sites…
Often evident at birth Occasionally manifest later in life Different clinical course – Generally stable over time (nevus of Ota and Ito) – Resolution with time (Mongolian spot) Blue to gray macule/patch…
Lower > upper extremities • 2/3 of cases arise in dermal/subcutaneous tissues • Local, often repeated, recurrences in up to 50-60% of cases (unrelated to histologic grade) • Intermediate- and high-grade malignant neoplasms…
Small cells with scant cytoplasm and small hyperchromatic nuclei; typically at periphery of tumor lobules Larger cells with eosinophilic cytoplasm and oval, vesicular nuclei; typically in centers of tumor lobules…
