Can have areas indistinguishable from cylindroma Usually encapsulated Tumor stroma has prominent vasculature • Malignant cylindroma/cylindrocarcinoma • Basal cell carcinoma Peripheral palisading with tumor-stroma retraction • Trichoblastoma Tumor lobule surrounded by fibroblastic stroma;…
Adult, fetal, and genital types Etiology/Pathogenesis • No association with tuberous sclerosis (unlike cardiac type) • Some fetal rhabdomyomas associated with nevoid basal cell carcinoma syndrome (Gorlin syndrome) Clinical Issues • Fetal type:…
pT1a: Melanoma ≤ 1.0 mm, no ulceration, no mitoses pT1b: Melanoma ≤ 1.0 mm, with ulceration &/or mitoses (≥ 1/mm²) • pT2: Melanoma > 1.0 – 2.0 mm in thickness pT2a:…
Especially lung, which are TTF-1(+), CK20(-) • Small cell melanoma • Lymphoma Clinical Photograph of MCCClinical photograph of Merkel cell carcinoma (MCC) shows a well-circumscribed, erythematous dermal nodule. (Courtesy J. Wu, MD.)…
DPN Showing Wedge-Shaped InfiltrateThis is a subtle case of deep penetrating nevus (DPN) on low-power examination. There are, however, dermally located subtle nests and fascicles of melanocytes . There is…
Often disseminated tumors, nodules, and papules Rapid spread to lungs, testes, brain, and oral cavity Often treated with multiagent chemotherapy • Often spares lymph nodes • Rare compared to other cutaneous T-cell…
Clinical Photograph of Actinic KeratosisClinical photograph of the scalp of an elderly patient shows multiple actinic keratoses (AKs) with prominent crusting. (Courtesy J. Wu, MD.) Bowenoid Actinic KeratosisBowenoid AK shows…
Crusted Scalp TumorThe tumor is crusted on the scalp of this elderly man. The skin-colored nodule on the left is benign, either a neurofibroma or a neurotized intradermal nevus. (Courtesy…
Male predominance • Forearm, trunk, and upper arm most common sites • Painful tender subcutaneous nodules Often multiple • Treatment: Simple surgical excision • Excellent prognosis Local recurrence very rare No risk of malignant…
Most frequent in females, usually younger patients Better prognosis (3-year survival rate of 56%, systemic variant: 22%) Microscopic • IVLBCL cells are large, with vesicular nuclear chromatin, distinct nucleoli, and frequent…
