IgA Acute Glomerulonephritis Associated with S. Aureus Robert B. Colvin, MD Key Facts Etiology/Pathogenesis Staphylococcus aureus, coagulase positive, often MRSA Increased risk with diabetes mellitus, neoplasia, old age Clinical Issues…
Lipoprotein Glomerulopathy Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis APOE gene mutations Clinical Issues Majority of cases reported in patients of Asian ancestry Microscopic Pathology Glomerular intracapillary…
Fibronectin Glomerulopathy Neeraja Kambham, MD Key Facts Terminology Nonimmune lobular glomerulopathy with massive mesangial and subendothelial fibronectin deposits Etiology/Pathogenesis Autosomal dominant inheritance Mutations in fibronectin FN1 gene documented recently in…
Nail-Patella Synorome Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Etiology/Pathogenesis LMX1B mutations Clinical Issues Iliac horns are pathognomonic (70% of cases) Absent, hypoplastic, or dystrophic nails Small, irregularly…
Focal Segmental Glomerulosclerosis Classification A. Brad Farris, III, MD Light microscopy of a case of collapsing FSGS shows a glomerulus with areas of sclerosis (silver stain). Immunofluorescence for C3 shows…
Podocin Deficiency Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Clinical Issues Proteinuria, may be nephrotic range 90% of familial cases progress to ESRD within ˜ 6 years 35%…
Uterus, Endometrium: Diagnosis The depth of invasion of endometrial carcinoma into the myometrium is an important predictor of the likelihood of metastasis. The deepest extent of invasion is confirmed by…
Lung Mass: Diagnosis Pulmonary adenocarcinoma is most often seen in a peripheral location and may show “puckering” or indentation of the pleural surface if the visceral pleura is involved. (Courtesy…
Thin Basement Membrane Disease Helen Liapis, MD Joseph Gaut, MD, PhD Key Facts Clinical Issues Presents with persistent microscopic hematuria Autosomal dominant inheritance 1-5% of population Microscopic Pathology Minimal changes…
Lyme Disease Membranoproliferative Glomerulonephritis Neeraja Kambham, MD Key Facts Terminology Immunological renal manifestation of MPGN, type 1 due to Borrelia burgdorferi infection Clinical Issues High level of clinical suspicion is…
