B-cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-cell Lymphoma and Burkitt Lymphoma Carlos E. Bueso-Ramos, MD, PhD Key Facts Terminology Aggressive B-cell lymphoma with morphological and genetic features…
Lymphadenopathy Associated with Joint Prostheses Roberto N. Miranda, MD Key Facts Terminology Lymphadenopathy caused by abraded metal debris and cementing substances drained from sites of joint prostheses Etiology/Pathogenesis Hip and…
Diffuse Large B-cell Lymphoma, NOS, Immunoblastic Francisco Vega, MD, PhD Key Facts Terminology Diffuse proliferation of large neoplastic B cells with immunoblastic cytologic features Immunoblasts must be > 90% of…
Richter Syndrome Sergej Konoplev, MD, PhD Key Facts Terminology Aggressive lymphoma arising in patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) Subtypes Common: Diffuse large B-cell lymphoma Uncommon: Classical Hodgkin…
ALK− Anaplastic Large Cell Lymphoma Francisco Vega, MD, PhD Key Facts Terminology Lymphoma histologically resembling spectrum of ALK(+) ALCL, with strong and uniform expression of CD30, but lacking ALK expression…
Mixed Cellularity Hodgkin Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology Subtype of classical Hodgkin lymphoma (CHL) with diffuse or interfollicular pattern, without nodular fibrosis Etiology/Pathogenesis Epstein-Barr virus (EBV)…
Plasmablastic Lymphoma Arising in HHV8+ Multicentric Castleman Disease L Jeffrey Medeiros, MD Key Facts Terminology PBL-MCD is a monoclonal proliferation of HHV8(+) plasmablasts that express IgMλ and arise in MCD…
Protocol for Examination of Non-Hodgkin Lymphoma Specimens L. Jeffrey Medeiros, MD Non-Hodgkin Lymphoma/Lymphoid Neoplasms: Biopsy, Resection Surgical Pathology Cancer Case Summary (Checklist) Specimen (select all that apply) ____ Lymph node(s)…
ALK+ Diffuse Large B-cell Lymphoma Tariq Muzzafar, MBBS Key Facts Etiology/Pathogenesis ALK gene abnormalities at chromosome 2p23 appear to be key transforming event Result in formation of fusion genes and…
Diffuse Large B-cell Lymphoma, NOS, Centroblastic Francisco Vega, MD, PhD Key Facts Terminology Diffuse proliferation of large neoplastic B cells composed predominantly of centroblasts Typical: Medium to large cells (10-14…
