Keratoacanthoma David Cassarino, MD, PhD Key Facts Terminology Keratoacanthoma (KA) Very well-differentiated SCC variant Etiology/Pathogenesis Similar to other forms of SCC, typically related to chronic solar (UV) damage Clinical Issues…
Lymphoepithelioma-like Carcinoma of the Skin David Cassarino, MD, PhD Key Facts Terminology Lymphoepithelioma-like carcinoma of the skin (LELCS) Poorly differentiated carcinoma, most likely variant of SCC, with prominent inflammatory infiltrate…
Squamous Cell Carcinoma (and Variants) David Cassarino, MD, PhD Key Facts Terminology Squamous cell carcinoma (SCC) Malignant epithelial tumor of squamous keratinocytes Etiology/Pathogenesis Most cases are related to UV radiation…
Verrucous Carcinoma (and Variants) Elsa F. Velazquez, MD Key Facts Clinical Issues Unicentric tumors are more frequent but multicentric ones may occur Some cases may be associated with viral warts…
Penile and Vulvar Intraepithelial Neoplasia Elsa F. Velazquez, MD Key Facts Terminology Most warty, basaloid, and mixed VIN and PeIN replace 2/3 to entire thickness of epithelium (VIN III and…
Squamous Cell Carcinoma In Situ (Bowen Disease) David Cassarino, MD, PhD Key Facts Terminology Squamous cell carcinoma in situ (SCCis) Synonyms: Bowen disease, squamous intraepithelial neoplasia Full thickness intraepidermal atypia…
Bowenoid Papulosis Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis Most often related to HPV 16 Clinical Issues Often multifocal Benign-looking papules Usually affecting skin of shaft in males Affecting labia…
Actinic Cheilitis David Cassarino, MD, PhD Key Facts Terminology Actinic cheilitis (AC) Actinic keratosis of lip Etiology/Pathogenesis Chronic sun exposure, especially UVB rays Clinical Issues Excellent in most cases, low…
Actinic Keratosis David Cassarino, MD, PhD Key Facts Terminology Actinic keratosis (AK) Solar keratosis Atypical intraepidermal proliferation of keratinocytes typically confined to basilar portion of epidermis Clinical Issues Older adults…
Toker Cell Hyperplasia Christine J. Ko, MD Key Facts Terminology Increase in number of Toker cells in epidermis Absence of underlying ductal carcinoma Mimics Paget disease of the nipple Clinical…
