Fig. 2.1. Polymer-based detection system, providing amplification of the signal, with low background and excellent reproducibility. ♦ The “primary” antibody binds to the test antigen in the tissue section;…
Fig. 32.1. Ovarian serous surface inclusion lined by a flattened serous epithelium. Serous surface inclusions lack associated granulosa cells or luteinized stromal cells. Follicular Cyst Clinical ♦ Follicular cysts…
Fig. 17.1. Chronic myelogenous leukemia. Peripheral blood smear with increased granulocytes with left shift, including increased basophils. Definition ♦ MPN associated with the BCR/ABL1 gene fusion of marrow stem cells,…
Markers Tumors Staining pattern Comments/potential pitfalls MDM2/ CDK4 Well-differentiated liposarcoma Dedifferentiated liposarcoma Intimal sarcoma Nuclear 10% of well-dedifferentiated liposarcomas are negative by IHC and may need FISH for MDM2 amplification…
Fig. 19.1. Acute spongiotic dermatitis with spongiotic microvesicles. • In acute spongiotic dermatitis, the epidermis retains its normal “basket-weave” stratum corneum. The epidermis also has pale keratinocytes and spongiosis with…
Characteristics Partial mole Early complete mole Complete mole Ploidy 3 N 2 N 2 N Villous p57KIP2 positivity + − − Dimorphic villous populations + − − Dysmorphic villi +…
(1) Department of Hematology Oncology, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, CA 92675, USA (2) Department of Pathology, Keck School of Medicine, University of Southern California, Los…
Follicular hyperplasia Follicular lymphoma Younger patients Normal follicle density Older patients Increased follicle density (back to back) Follicles vary in size and shape Well-defined mantle zone Cellular polarization present Heterogeneous…
