and Natalia Buza1 (1) Department of Pathology, Yale University School of Medicine, New Haven, CT, USA KeywordsMetastatic tumors of ovaryMetastatic intestinal adenocarcinomaKrukenberg tumorMetastatic pancreatobiliary adenocarcinomasMetastatic appendiceal tumorsMetastatic breast carcinomaMetastatic cervical…
and Natalia Buza1 (1) Department of Pathology, Yale University School of Medicine, New Haven, CT, USA KeywordsGestational trophoblastic diseaseComplete hydatidiform molePartial hydatidiform moleInvasive hydatidiform moleGestational choriocarcinomaPlacental site trophoblastic tumorEpithelioid trophoblastic…
and Natalia Buza1 (1) Department of Pathology, Yale University School of Medicine, New Haven, CT, USA KeywordsIntraoperative consultationFrozen section diagnosisGynecologic pathologyTissue samplingSurgical managementDiagnostic accuracyCommunication The Purpose of Frozen Section Evaluation…
Electron Microscopy Ashima Agarwal Frances V. White I. INTRODUCTION. Transmission electron microscopy (EM) has been used by surgical pathologists over the past 50 years for the diagnosis of a wide…
Imaging Technologies in Surgical Pathology: Virtual Microscopy and Telepathology Jochen K. Lennerz Michael Isaacs Erika Crouch John D. Pfeifer I. CONVENTIONAL LIGHT MICROSCOPY remains the core tool in diagnostic surgical…
Biospecimen Banking Mark Watson I. SIGNIFICANCE TO PATHOLOGY AND TRANSLATIONAL RESEARCH. National initiatives such as The Cancer Genome Atlas (http://cancergenome.nih.gov) and the 1,000 Genomes Project (http://www.1000genomes.org/) have greatly enhanced the…
Microarrays Mark Watson I. INTRODUCTION. Nucleic acid microarrays are an ordered arrangement of DNA molecules (probes or features) on a solid surface. A sample of DNA or RNA derived from…
Direct and Indirect Methods for DNA Sequence Analysis TuDong Nguyen Barbara Zehnbauer John D. Pfeifer I. INTRODUCTION. Clinical molecular diagnostic methods have been integrated into many laboratory disciplines, and guidelines…
Fluorescence in Situ Hybridization TuDong Nguyen Arie Perry Anjum Hassan Fluorescence in situ hybridization (FISH) utilizes tagged probes that bind to chromosome-specific DNA sequences of interest, thereby allowing for the…
Cytogenetics Shashikant Kulkarni Hussam Al-Kateb Catherine Cottrell I. INTRODUCTION. The three significant milestones in the history of clinical cytogenetics are the preparation of chromosome spreads from peripheral blood cultures (Exp…
