Fig. 16.1 Conceptual model of and strategy against the development of age-related hearing loss Acknowledgements This work was supported by grants from Ministry of Education, Culture, Sports, Science & Technology,…
© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_14 14. Genetics and Age-Related Hearing Loss Robert D. Frisina1 and D. Robert Frisina1…
Antineoplastics Aminoglycosides Loop diuretics Antimalarials Macrolides NSAIDS Carboplatin Amikacin Azosemide Chloroquine Azithromycin Aspirin Cisplatin Dihydrostreptomycin Bumetanide Chloroquine phosphate Erythromycin Etodolac Nedaplatin Gentamicin Ethacrynic acid Hydroxychloroquine Fenoprofen Oxaliplatin Kanamycin Furosemide Quinacrine…
Davis JM, Elfenbein J, Schum R, Bentler RA (1986) Effects of mild and moderate hearing impairments on language, educational, and psychosocial behavior of children. J Speech Hear Disord 51(1):53–62PubMed de…
Fig. 11.1 In vivo, cisplatin (left) is hydrolyzed to the monohydrated cisplatin complex (MHC; middle and right), which is highly reactive when protonated ([MHC]+; middle) When performing kinetic studies of…
Population Drug and dose Noise Outcome Attias et al. (1994) 300 normal-hearing (<20 dB HL from 1 to 8 kHz) recruits completing 2 months of basic training; ages 17.7–18.5…
Staecker H, Zheng QY, Van De Water TR (2001) Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol 121(6):666–672PubMedCentralPubMed Suemori S, Shimazawa M, Kawase K, Satoh M, Nagase…
Fig. 2.1 Redox chemistry of free radicals in vivo. Oxygen (O2) reacts slowly to accept a single electron and produce superoxide (O2 •−) in vivo [1], while two electrons can…
Modifiable Non-modifiable Noise and hearing protection use Age Diet Sex Other lifestyle (smoking, alcohol consumption, exercise) Race/ethnicity Other environmental determinants (e.g., chemicals) Genetics Possibly modifiable Health, disease, medications Socioeconomic status/education…
© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_1 1. Introduction: Free Radicals in ENT Pathology Josef Miller1 , Colleen G. Le…
