Basic Mechanisms Underlying Noise-Induced Hearing Loss
Fig. 7.1 Changes in auditory brain stem response (ABR) following a 106 dB, 2–20 kHz noise for 2 h in a mouse that had only a temporary threshold shift (TTS)….
PATHOLOGY & LABORATORY MEDICINE
Loss of Residual Hearing Initiated by Cochlear Implantation: Role of Inflammation-Initiated Cell Death Pathways, Wound Healing and Fibrosis Pathways, and Potential Otoprotective Therapies
Fig. 19.1 A scanning electron micrograph of the lower basal turn of a human cochlea. The arrow indicates the direction of insertion of a cochlear implant electrode array into the…
A Question of Balance: Free Radicals and Cochlear Homeostasis
Fig. 3.1 “Core” reactions that produce or remove reactive oxygen species There remains debate among serious chemists (which this author makes no claim to be) as to which of the…
Cellular Mechanisms of Age-Related Hearing Loss
Fig. 15.1 General hallmarks of aging. A detailed explanation of the relevance of this hallmarks and its particularization to ARHL is given in the text (Reproduced with permission of Cell)…
The Role of Oxidative Stress in Idiopathic Sudden Sensorineural Hearing Loss and Meniere’s Disease
Fig. 21.1 Pretreatment pure-tone audiogram of a patient presenting with right profound sudden sensorineural hearing loss Fig. 21.2 Posttreatment audiogram of the same patient treated with a course of intratympanic…
Overarching Challenges of Free Radicals in ENT Pathology
© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_25 25. Overarching Challenges of Free Radicals in ENT Pathology…
Free Radicals and Sleep Apnea
Authors Group Oxidative stress markers Changes in oxidative stress markers CPAP results Reference Christou et al. (2003) Human adults Antioxidant capacity, TEAC In severe OSAS, TEAC reduced Not measured [5]…
Free Radicals in Nasal and Paranasal Diseases
© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_24 24. Free Radicals in Nasal and Paranasal Diseases Vaclav Holecek1 ,…
Strategies for the Treatment of Hereditary Hearing Loss
Gene Protein Other names Common mutations Associated features GJB2 Connexin 26 DFNB1 35delG, M34T, 167delT, V37I, 235delC Rarely skin conditions SLC26A4 (PDS) Pendrin DFNB4 His723Arg, Thr416Pro, Leu236Pro Mondini deformity, euthyroid…
Genes and Hearing Loss: Relationship to Oxidative Stress and Free Radical Formation
Alkan C, Coe BP, Eichler EE (2011) Genome structural variation discovery and genotyping. Nat Rev Genet 12(5):363–376PubMedCentralPubMed Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin IJ, Miller JM, Lomax…
