Fig. 11.1 In vivo, cisplatin (left) is hydrolyzed to the monohydrated cisplatin complex (MHC; middle and right), which is highly reactive when protonated ([MHC]+; middle) When performing kinetic studies of…

  Population Drug and dose Noise Outcome Attias et al. (1994) 300 normal-hearing (<20 dB HL from 1 to 8 kHz) recruits completing 2 months of basic training; ages 17.7–18.5…

Staecker H, Zheng QY, Van De Water TR (2001) Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol 121(6):666–672PubMedCentralPubMed Suemori S, Shimazawa M, Kawase K, Satoh M, Nagase…

Modifiable Non-modifiable Noise and hearing protection use Age Diet Sex Other lifestyle (smoking, alcohol consumption, exercise) Race/ethnicity Other environmental determinants (e.g., chemicals) Genetics Possibly modifiable Health, disease, medications Socioeconomic status/education…

© Springer International Publishing Switzerland 2015Josef Miller, Colleen G. Le Prell and Leonard Rybak (eds.)Free Radicals in ENT PathologyOxidative Stress in Applied Basic Research and Clinical Practice10.1007/978-3-319-13473-4_1 1. Introduction: Free Radicals in ENT Pathology Josef Miller1  , Colleen G. Le…

Fig. 4.1 A highly stylized auditory hair cell is drawn in this schematic. The cell is depicted to be under the stress of typical pathological triggers of noise, aging, and…

Fig. 5.1 Proposed mechanisms of oxidative stress by redox-inactive toxic metals 5.2 Lead Lead is a bluish-gray metal found naturally in the earth’s crust. Because of its versatility, lead has…