Eventually destroys hepatic parenchyma  Solid, epithelioid, and spindled areas may be present • Immunopositive for vascular markers: CD31, CD34, factor VIII • Nuclear staining for transcription factors FLI-1 and ERG helps in…

 Depending on severity of portal hypertension, biliary infection, and renal disease Microscopic • Marked portal expansion by fibrous tissue  Portal-to-portal bridging fibrosis with broad septa • Increased number of irregularly shaped, ectatic,…

 Liver  Pancreas  Heart  Thyroid  Minor salivary glands • Abnormal iron studies • Liver and multiorgan failure Macroscopic • Shrunken liver • Cirrhosis Microscopic • Marked lobular necrosis with collapse • Regenerative nodules • Pseudoacinar formation • Intracanalicular bile…

 Inflammation may be sparse in early disease  Edema and congestion seen in early disease • Inflammation dominated by neutrophils and variable necrosis in later stages of disease • Widespread fibroblastic proliferation can…

 One of most common gastrointestinal diseases worldwide – Particularly common in Scandinavia, Chile – In United States, estimated 10-20% of population have gallstones • 2 main types: Cholesterol stones and pigment stones  Cholesterol…

 Most often gram-negative infection • Mechanisms uncertain but probably involve decreased activity and expression of canalicular and sinusoidal transporters Clinical Issues • Patients are systemically ill and typically jaundiced • Enzyme elevations may…

 Wide range of morphologic findings ranging from pleomorphic epithelioid cells to multinucleated giant cells to spindle cells Clinical Issues • Rare • Prognosis is dismal, often < 1 year • Surgical resection is…

 Changes are centered around minor papilla and involve “groove” between pancreas and duodenum  May mimic pancreatic neoplasm, including cystic neoplasm Microscopic • Duodenal wall around minor ampulla is thickened with marked…

 Reported range: 16-66 years • Benign cyst without risk of malignant transformation Macroscopic • Unilocular to multilocular thin-walled cyst(s) filled with serous fluid • Size range: 1.5-10.0 cm Microscopic • Cysts lined by single…

 Biochemical evidence of cholestasis • Normal extrahepatic bile ducts • Variable prognosis, ranging from benign clinical course to progressive disease requiring liver transplantation Microscopic • Loss of interlobular bile ducts in > 50%…