Well-differentiated neuroendocrine neoplasm (WDNEN): Grades 1 and 2 Poorly differentiated neuroendocrine carcinoma (PDNC): Grade 3 – Small cell carcinoma, large cell neuroendocrine carcinoma Clinical Issues • WDNEN: All tumors have potential to…
Classified as main duct, combined, or branch duct type Clinical Issues • 20-50% of resected cystic pancreatic tumors Incidence increasing due to increased incidental detection on imaging for other reasons • Most…
Pancreatic adenocarcinoma and CP may coexist Microscopic • Fibrosis and chronic inflammation Variable extent and distribution of fibrosis Irregular atrophy and obliteration of pancreatic acini and ducts Retention of normal lobular…
Usually represents liver involvement by infectious mononucleosis Elevated serum transaminase, alkaline phosphatase, and bilirubin levels Self limited in majority of cases • EBV-associated lymphoproliferative disorders In immunocompromised individuals due to uncontrolled…
3 types, based on identification of serum autoantibodies Clinical Issues • Affects patients of all ages, predominantly women • Chronic disease by definition but may present clinically as acute or fulminant hepatitis…
1:5,000 to 1:19,000 newborns Clinical Issues • Most common cause of pathologic infant jaundice Conjugated hyperbilirubinemia – Neonatal jaundice – Dark urine and pale stools – Hepatomegaly • Associated extrahepatic congenital anomalies present in up…
Chronic inflammation – Chronic cholecystitis, cholelithiasis, chronic biliary infections Porcelain gallbladder Primary sclerosing cholangitis Gastrointestinal polyposis Clinical Issues • Most often occurs in India, Chile, Pakistan, and Ecuador Females more often affected…
Intraampullary: Arise in ampulla (lined by pancreatobiliary epithelium) Periampullary: Arise in duodenal surface of papilla (lined by intestinal epithelium) Clinical Issues • 5-year overall survival rate: 40% Determined by histologic type,…
Pancreatic Neuroendocrine TumorA well-circumscribed solid mass in the pancreas is typical of low-grade neuroendocrine tumors. Nested ArchitectureThe tumor cells show a nested pattern of growth. The individual tumor cells have…
Caused by mutations in SERPINA1 gene • Deficiency is characterized by emphysema and chronic liver disease Etiology/Pathogenesis • Mutations result in defective secretion of molecule, accumulation in hepatocytes, and decreased serum A1AT…
