Late Consequences of Cancer and Its Treatment
120e Carcinoma of Unknown Primary Gauri R. Varadhachary, James L. Abbruzzese Carcinoma of unknown primary (CUP) is a biopsy-proven malignancy for which the anatomic site of origin remains unidentified…
GENERAL & FAMILY MEDICINE
Heavy Metal Poisoning
Metals pose a significant threat to health through low-level environmental as well as occupational exposures. One indication of their importance relative to other potential hazards is their ranking by the…
Osteoarthritis
389 Relapsing Polychondritis Carol A. Langford Relapsing polychondritis is an uncommon disorder of unknown cause characterized by inflammation of cartilage predominantly affecting the ears, nose, and laryngotracheobronchial tree. Other manifestations…
Acute Appendicitis and Peritonitis
FIGURE 351-8 Wireless capsule endoscopy image in a patient with Crohn’s disease of the ileum shows ulcerations and narrowing of the intestinal lumen. (Courtesy of Dr. S. Reddy, Gastroenterology Division, Department…
Clostridium difficile Infection, Including Pseudomembranous Colitis
The mainstay of treatment is adequate rehydration. The treatment of cholera and other dehydrating diarrheal diseases was revolutionized by the promotion of oral rehydration solution (ORS), the efficacy of which…
Infections in Veterans Returning from Foreign Wars
According to the World Tourism Organization, international tourist arrivals grew dramatically from 25 million in 1950 to >1 billion in 2012. Not only are more people traveling; travelers are…
Disorders of the Thyroid Gland
FIGURE 404-4 Simplified approach to the differential diagnosis of diabetes insipidus. When symptoms suggest diabetes insipidus (DI), the syndrome should be differentiated from a genitourinary (GU) abnormality by measuring the 24-h…
Systemic Sclerosis (Scleroderma) and Related Disorders
380 Rheumatoid Arthritis Ankoor Shah, E. William St. Clair INTRODUCTION Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. It is the…
Pneumococcal Infections
(See also Chap. 148) In addition to receiving antibiotic prophylaxis, transplant recipients should be vaccinated against likely pathogens (Table 169-6). In the case of HSC transplant recipients, optimal responses cannot…
Neoplasms of the Lung
FIGURE 105-4 Influence of vismodegib on the hedgehog (Hh) pathway. Normally, one of three Hh ligands (sonic [SHh], Indian, or desert) binds to patched homolog 1 (PTCH1), causing its degradation and…
