Overview The hematologic system comprises a variety of different tissue and cell types. These include a diverse range of cell functions and organs, including the bone marrow, spleen, and lymph…
Overview Immunohistochemistry (IHC), or immunocytochemistry (ICC), is a laboratory technique used to detect specific antigens (i.e., proteins) in tissues or cells based on antigen-antibody recognition; it seeks to exploit the…
Overview Tumors of soft tissue and bone are a diverse family, and categorization continues to evolve as more insight is gained into their patterns of differentiation and the underlying molecular…
General Principles of Molecular Biology Immunohistochemistry (IHC) is a common technique used for the detection of protein expression in various tissue samples. In modern pathology practice, this methodology is expanded…
Chapter 2 Water, sodium and potassium Introduction Water distribution Water accounts for approximately 60% of body weight in men and 55% in women, the difference reflecting the typically greater body…
Chapter 3 Hydrogen ion homoeostasis and blood gases Introduction The normal processes of metabolism result in the net formation of 40–80 mmol of hydrogen ions per 24 h, principally from the oxidation…
Chapter 4 The kidneys Introduction The kidneys have three major functions: • excretion of waste • maintenance of extracellular fluid (ECF) volume and composition, including acid-base balance • hormone synthesis….
Chapter 14 Lipids, lipoproteins and cardiovascular disease Introduction The major lipids present in the plasma are fatty acids, triglycerides, cholesterol and phospholipids. Other lipid-soluble substances, present in much smaller amounts…
Chapter 11 Disorders of carbohydrate metabolism Introduction Glucose is a major energy substrate. It typically provides more than half the total energy requirements of a typical ‘western’ diet and is…
Chapter 15 The locomotor and nervous systems Introduction It is convenient to consider these systems in the same chapter. Although the diseases that affect them may show little or no…
