Annular Elastolytic Giant Cell Granuloma Cary Chisholm, MD Key Facts Terminology Granulomatous infiltrate with phagocytosis and destruction of elastic fibers Clinical Issues Erythematous papules and plaques, which are often annular…
Amyloidosis Kajsa Affolter, MD Key Facts Clinical Issues SA: Non-pruritic, waxy papules on scalp, neck, and, face with predilection for periorbital area and plaque-like lesions on hands and flexural areas…
Foreign Body Granuloma Brian J. Hall, MD John C. Hall, MD Key Facts Terminology Granulomatous inflammation as a response to traumatically introduced substances Clinical Issues Firm, usually colorless nodule that…
Granuloma Annulare Christine J. Ko, MD Key Facts Clinical Issues Most commonly localized over backs of hands/feet or on arms/legs Pink-red to slightly brown or purple 1-2 mm papules in…
Juvenile Xanthogranuloma Christine J. Ko, MD Key Facts Microscopic Pathology Dermal nodule of mixed inflammation Predominantly histiocytes Varying morphologies: Vacuolated, xanthomatized, scalloped, oncocytic, spindle-shaped Admixed lymphocytes, eosinophils, occasional neutrophils and…
Necrolytic Migratory Erythema Cary Chisholm, MD Key Facts Terminology Skin manifestation of glucagonoma syndrome Clinical Issues Trunk, groin, extremities, thighs, and buttocks are most frequently involved Annular or round erythematous…
Porphyria Cutanea Tarda Michael W. Peterson, DO Cary Chisholm, MD Clay J. Cockerell, MD Key Facts Etiology/Pathogenesis Caused by deficiency in enzyme uroporphyrinogen decarboxylase Clinical Issues Hyperpigmentation, vesicles, bullae, and…
Relapsing Polychondritis Aparche Yang, MD, FAAD Sharon Jacob, MD Key Facts Terminology Chronic multisystem disease characterized by remitting and relapsing inflammation and destruction of cartilaginous and other proteoglycan-rich tissue Clinical…
Morphea/Scleroderma Sudeep Gaudi, MD Drazen M. Jukic, MD, PhD Key Facts Terminology Scleroderma limited to skin, subcutaneous tissue, and underlying muscle and bone Etiology/Pathogenesis Environmental trigger in a genetically predisposed…
Erythema Induratum Cary Chisholm, MD Key Facts Terminology Granulomatous lobular panniculitis with vasculitis Etiology/Pathogenesis Mycobacterium species, Brucella species, hepatitis C Clinical Issues Usually multiple painful nodules on calves or shins…
