Erythema Induratum



Erythema Induratum


Cary Chisholm, MD





Key Facts


Terminology



  • Granulomatous lobular panniculitis with vasculitis


Etiology/Pathogenesis



  • Mycobacterium species, Brucella species, hepatitis C


Clinical Issues



  • Usually multiple painful nodules on calves or shins


  • Nodules may coalesce into larger plaques


  • Often will resolve with scarring and recur


  • Ulceration may occur


Microscopic Pathology



  • Lobular or septolobular panniculitis


  • Fat necrosis, fibrosis of septae


  • Histiocytes, multinucleated giant cells are numerous


  • Granulomas are common


  • Remainder of infiltrate may contain neutrophils, lymphocytes, and plasma cells


  • Vasculitis of intralobular vessels







Erythema induratum shows an indurated image lower leg with an early vasculitic-appearing lesion image. The patient had a positive PPD and appeared to respond to anti-TB antibiotics.






Erythema induratum is a predominantly lobular panniculitis. Here, there is prominent fat necrosis image with a mixed inflammatory cell infiltrate image.


TERMINOLOGY


Synonyms



  • Erythema induratum of Bazin, nodular vasculitis


Definitions



  • Granulomatous lobular panniculitis with vasculitis


ETIOLOGY/PATHOGENESIS


Infectious Agents



  • Mycobacterium species, Brucella species, hepatitis C


CLINICAL ISSUES


Epidemiology

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Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Erythema Induratum

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