Annular Elastolytic Giant Cell Granuloma



Annular Elastolytic Giant Cell Granuloma


Cary Chisholm, MD










Multiple yellow-orange annular plaques on the upper trunk of this patient clinically mimic necrobiosis lipoidica. The patient did not have diabetes and the biopsy was compatible with AEGCG.






Annular elastolytic giant cell granuloma is characterized by a histiocytic infiltrate with multinucleated giant cells image. Palisading image may be present.


TERMINOLOGY


Abbreviations



  • Annular elastolytic giant cell granuloma (AEGCG)


Synonyms



  • Giant cell elastophagocytosis


Definitions



  • Granulomatous infiltrate with phagocytosis and destruction of elastic fibers



    • Typically arising in areas with minimal actinic damage


  • Some authors contend that AEGCG is not a unique diagnosis



    • AEGCG is a term for a spectrum that includes other individual diagnoses



      • Granuloma annulare


      • Actinic granuloma of O’Brien


      • Atypical necrobiosis lipoidica


      • Granuloma multiforme


    • Similar findings: Histiocytic infiltrate with multinucleated giant cells (MNGCs)



      • Phagocytosis of mucin or elastic fibers


      • ± necrobiosis

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Annular Elastolytic Giant Cell Granuloma
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