Sudeep Gaudi, MD

Drazen M. Jukic, MD, PhD

A lesion of morphea en plaque is characteristically located on the trunk under an area of pressure (bra line). Note the violaceous peripheral rim (“lilac ring”) and white, sclerotic center.

Pictured are lesions of generalized morphea. This patient presented with indurated plaques image measuring at least 3 cm in greatest dimension over his trunk and upper and lower extremities.



  • Morphea: Localized scleroderma


  • Most common subtype of scleroderma (group of fibrosing disorders that result from imbalance between collagen production and destruction)

    • Clinically heterogeneous disease process that is localized to the skin and subcutaneous tissues with possible involvement of underlying muscle and bone

      • Underlying central nervous system may also be affected in cases of face and head involvement



  • Precise etiology remains mystery

  • Evidence suggests microvascular injury induces profibrotic cytokines following environmental insult in genetically predisposed individual

    • These cytokines lead to increased collagen production and decreased collagen destruction

  • Genetic

    • Possible host factors include autoimmunity and microchimerism

  • Environmental

    • Possible insults include radiation, trauma, medications, and infection (potential link to certain Borrelia species, particularly in Europe)



  • Incidence

    • 0.4-2.7 per 100,000 people

  • Age

    • Prevalence is equal in adults and children

      • Approximately 90% of afflicted children present between 2 and 14 years of age

      • Mean age of presenting adults is mid-40s

  • Gender

    • About 2-4x more common in females than males

  • Ethnicity

    • Affects all races, but more common in whites

      • Approximately 70-80% of patients examined in ethnically heterogeneous clinical populations are white


Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Morphea/Scleroderma

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