Mycobacterial Infection
Mycobacterial Infection Tariq Muzzafar, MBBS Key Facts Clinical Issues High index of suspicion essential for diagnosis Definitive diagnosis by histology and culture of LN Molecular methods enable quicker identification of…
Toxoplasma Lymphadenitis
Toxoplasma Lymphadenitis Carlos E. Bueso-Ramos, MD, PhD Key Facts Etiology/Pathogenesis Toxoplasma gondii is parasitic protozoan Cat is definitive host for sexual stage of reproduction Trophozoite-containing oocysts are eliminated in feces…
Chronic Granulomatous Lymphadenitis
Chronic Granulomatous Lymphadenitis C. Cameron Yin, MD, PhD Key Facts Terminology Granulomatous inflammation is specific type of inflammatory response Characterized by accumulation of modified macrophages (epithelioid cells) Initiated by infectious…
Rosai-Dorfman Disease
Rosai-Dorfman Disease L. Jeffrey Medeiros, MD Roberto N. Miranda, MD Key Facts Terminology Rosai-Dorfman disease (RDD) and sinus histiocytosis with massive lymphadenopathy are equivalent terms Etiology/Pathogenesis Unknown; histologic features are…
Kimura Disease
Kimura Disease C. Cameron Yin, MD, PhD Key Facts Terminology Chronic inflammatory disease that affects subcutaneous tissue and regional lymph nodes Etiology/Pathogenesis Unknown; infectious cause suspected Clinical Issues Mainly in…
Infectious Mononucleosis Lymphadenitis
Infectious Mononucleosis Lymphadenitis Pei Lin, MD Key Facts Etiology/Pathogenesis Epstein-Barr virus infection Clinical Issues Fever Pharyngitis Lymphadenopathy Microscopic Pathology Follicular and interfollicular hyperplasia Range of cells from small mature forms…
Hyaline Vascular Castleman Disease
Hyaline Vascular Castleman Disease Pei Lin, MD Key Facts Clinical Issues Young adults Lymphadenopathy, localized Excision is usually curative Microscopic Pathology Large follicles with regressed (involuted) germinal centers 2 or…
Progressive Transformation of Germinal Centers
Progressive Transformation of Germinal Centers Pei Lin, MD Key Facts Terminology Progressive transformation of germinal centers (PTGC) Clinical Issues Young adults most commonly affected Asymptomatic localized lymphadenopathy in most patients…
Cryptorchidism
Cryptorchidism Steven S. Shen, MD, PhD Key Facts Terminology Testis present outside scrotum and cannot be moved into scrotum Clinical Issues Most common birth defect of male genitalia 1% of…
Vasculitis, ANCA-Related
Vasculitis, ANCA-Related Monica P. Revelo, MD, PhD Key Facts Terminology Systemic vasculitis involving small to medium-sized vessels associated with or caused by ANCA Kidney involvement is characterized by prominent crescents…
