Undifferentiated Pleomorphic Sarcoma With Prominent Inflammation Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Pleomorphic undifferentiated malignant neoplasm with histiocytic and inflammatory cell infiltrate Microscopic Pathology Sheets of variably atypical…
Fibroepithelial Stromal Polyp Elizabeth A. Montgomery, MD Key Facts Clinical Issues Polypoid lesions presenting in vagina or vulva Possible relationship to hormonal factors Simple excision; occasional recurrences, especially with subsequent…
Undifferentiated Pleomorphic Sarcoma With Giant Cells Khin Thway, BSc, MBBS, FRCPath Key Facts Terminology Malignant pleomorphic spindle and polygonal cell sarcoma with osteoclast-type giant cells Tumor morphology shared with several…
Dermatofibrosarcoma Protuberans Thomas Mentzel, MD Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Dermatofibrosarcoma represents superficially located low-grade fibroblastic sarcoma that may show progression to fibrosarcomatous dermatofibrosarcoma protuberans Clinical Issues…
Plexiform Fibrohistiocytic Tumor Julie C. Fanburg-Smith, MD Aaron Auerbach, MD Key Facts Terminology Borderline tumor of fibrohistiocytic phenotype with histiocytic and osteoclast-type giant cells rich; cannonball-like pattern &/or spindled fibroblastic…
Miscellaneous Xanthomas Jonathan B. McHugh, MD Key Facts Terminology Mass-forming collection of lipidized macrophages Reactive process usually resulting from altered serum lipid levels Etiology/Pathogenesis Associated with hereditary lipoproteinemias and occasionally…
Multinucleate Cell Angiohistiocytoma David S. Cassarino, MD, PhD Key Facts Terminology Proliferation of vessels and multinucleated stromal cells Etiology/Pathogenesis May be nonneoplastic reactive process Clinical Issues Usually occur in patients…
Cellular Neurothekeoma Cyril Fisher, MD, DSc, FRCPath Key Facts Terminology Multinodular dermal tumor composed of nests of rounded cells separated by delicate fibrous septa Differs from dermal nerve sheath myxoma…
Plexiform Xanthoma Jonathan B. McHugh, MD Key Facts Clinical Issues Rare Tend to occur in young adults (4th decade) Most often occur in extremities Elbow and knee regions most frequent…
Reticulohistiocytoma David S. Cassarino, MD, PhD Key Facts Terminology Proliferation of histiocytes with abundant dense, glassy-appearing eosinophilic cytoplasm Clinical Issues Usually occurs in adults > 40 years old, but cases…
