Undifferentiated Pleomorphic Sarcoma With Prominent Inflammation



Undifferentiated Pleomorphic Sarcoma With Prominent Inflammation


Khin Thway, BSc, MBBS, FRCPath









Inflammatory malignant fibrous histiocytoma is shown with sheets of large cells with abundant foamy cytoplasm. The inflammatory background is apparent even at low power.






Inflammatory malignant fibrous histiocytoma contains a prominent infiltrate of neutrophils. Large atypical cells with vesicular nuclei and prominent nucleoli are also easily identifiable image.


TERMINOLOGY


Abbreviations



  • Inflammatory malignant fibrous histiocytoma (MFH)


Synonyms



  • Undifferentiated pleomorphic sarcoma with prominent inflammation


Definitions



  • Pleomorphic undifferentiated malignant neoplasm with large, variably atypical xanthomatous cells admixed with atypical spindle cells and prominent acute and chronic inflammatory cell infiltrate


  • Although designated as specific subtype of MFH, many of these are now thought to represent dedifferentiated liposarcomas


ETIOLOGY/PATHOGENESIS


Environmental Exposure



  • Etiology unknown for most cases


  • A few cases have occurred post radiation

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Undifferentiated Pleomorphic Sarcoma With Prominent Inflammation
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