Plexiform Xanthoma

Plexiform Xanthoma

Jonathan B. McHugh, MD

A multinodular proliferation with a plexiform architecture filling the dermis is typical of plexiform xanthoma. The deep nodules image tend to be more well developed than the superficial ones.

Medium-power view shows the typical appearance of plexiform xanthoma, with variably sized nodules arranged in a plexiform configuration and with associated fibrosis image.



  • Superficial (dermis/subcutis) nodular proliferation of lipid-laden macrophages with plexiform arrangement



  • Incidence

    • Rare

      • Only single case reports and small series in the literature

  • Age

    • Tend to occur in young adults (4th decade)

  • Gender

    • Men affected more frequently than women


Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Plexiform Xanthoma

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