Undifferentiated Pleomorphic Sarcoma With Giant Cells



Undifferentiated Pleomorphic Sarcoma With Giant Cells


Khin Thway, BSc, MBBS, FRCPath









Osteoclast-like giant cells are admixed with tumor cells in this example of giant cell MFH. The giant cells show plump nuclei with prominent nucleoli but lack the pleomorphism and marked atypia of the tumor cells.






Osteoclast-like giant cells image and tumor giant cells image are often intermingled. Note the much larger size of tumor nuclei compared to those of the giant cells.


TERMINOLOGY


Abbreviations



  • Giant cell malignant fibrous histiocytoma (MFH)


Synonyms



  • Malignant giant cell tumor of soft parts


  • Giant cell sarcoma


  • Malignant osteoclastoma


  • Pleomorphic undifferentiated sarcoma with giant cells


Definitions



  • Malignant pleomorphic spindle and polygonal cell sarcoma with osteoclast-type giant cells


  • Morphology shared with several other pleomorphic malignant tumors of other lineages

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Undifferentiated Pleomorphic Sarcoma With Giant Cells
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