Basicmedical Key

Papillary Carcinoma Yuri E. Nikiforov N. Paul Ohori DEFINITION Papillary carcinoma is a well-differentiated malignant tumor of thyroid follicular cells that shows a set of characteristic nuclear features. Although a…

Rare Primary Thyroid Nonepithelial Tumors and Tumor-Like Conditions Lester D.R. Thompson PRIMARY ANGIOSARCOMA Primary thyroid gland angiosarcoma is a malignant tumor of endothelial cell differentiation. This generally rare thyroid tumor…

Rare Primary Thyroid Epithelial Tumors Lester D.R. Thompson MUCOEPIDERMOID CARCINOMA Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm. By definition, an MEC contains a combination of mucinous and epidermoid components.1…

Medullary Carcinoma Paul W. Biddinger DEFINITION Medullary thyroid carcinoma is a malignant tumor of the thyroid gland that exhibits C-cell differentiation. Synonyms include C-cell carcinoma, solid carcinoma, solid amyloidotic carcinoma,…

Primary Thyroid Lymphoma Lester D.R. Thompson Christine Garcia Roth DEFINITION Primary thyroid gland lymphoma is an uncommon neoplasm that encompasses a heterogeneous group of diseases.1,2,3,4 Primary thyroid gland lymphomas are…

Principles of Molecular Diagnostics in Thyroid Samples Marina N. Nikiforova GENERAL PRINCIPLES OF MOLECULAR BIOLOGY Molecular diagnostics utilize the basic dogma of molecular biology that describes the relationship among DNA,…

Follicular Carcinoma Yuri E. Nikiforov N. Paul Ohori DEFINITION Follicular carcinoma is a malignant well-differentiated tumor of thyroid follicular cells that lacks the diagnostic nuclear features of papillary carcinoma. When…