Phenobarbital, Primidone Timothy Welty MECHANISM OF ACTION Primidone metabolized to phenobarbital Enhance γ-aminobutyric acid (GABA) receptor-mediated postsynaptic chloride currents Attenuates presynaptic calcium-dependent potentials EFFICACY Epilepsy—Monotherapy in New-Onset Epilepsy Study Type….
Oxcarbazepine Jerzy Szaflarski MECHANISM OF ACTION Oxcarbazepine blocks sodium-dependent action potentials on the basis of voltage- and use-dependent limitation of action potential firing (indirect effect). Monohydroxy derivative (MHD) reduces glutamatergic…
Levetiracetam Jennifer Cavitt MECHANISM OF ACTION Levetiracetam binds to the synaptic vesicle protein SV2A, and several lines of evidence indicate that this is how levetiracetam exerts its antiepileptic action1. EFFICACY…
Lamotrigine David Ficker MECHANISM OF ACTION Blocks voltage-activated Na channels Blocks release of glutamate and aspartate during repetitive firing Inhibits high-amplitude calcium currents EFFICACY Epilepsy—Monotherapy Trials Study Type. Randomized controlled…
Gabapentin Jennifer Cavitt MECHANISM Binds to α-2-δ subunit of voltage-gated calcium channels in the neuron Reduces depolarization-dependent calcium influx, modulating excitatory neurotransmitter release Gabapentin structurally similar to neurotransmitter γ-aminobutyric acid…
Carbamazepine Timothy Welty MECHANISM OF ACTION Blocks voltage-activated Na channels Reduces polysynaptic responses Blocks post-tetanic potentiation Depresses thalamic potentials Depresses bulbar and polysynaptic reflexes EFFICACY Epilepsy—Monotherapy in New-Onset Epilepsy Randomized…
Introduction and Instructions for Using Clinician’s Guide to Antiepileptic Drug Use Michael Privitera Antiepileptic Drugs in Epilepsy Treatment Antiepileptic treatments have a rich history, beginning in the ancient times and…
